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📌 Postoperative Evaluation of Articular Cartilage Repair
- Postoperative evaluation of articular cartilage repair usually includes the degree of osteochondral defect filling (thickness), graft signal intensity (overall heterogeneity), integration of the peripheral cartilage and bone interfaces, changes in the subchondral bone (e.g.edema and cysts), and presence of synovitis.
✅ Repair Tissue Signal
- Changes during maturation, with decreased signal intensity appearing hypointense compared to normal cartilage
- After 1 to 2 years, the defect should be filled with repair tissue, smoothly aligning with adjacent hyaline cartilage
✅ Outcomes of Microfracture
- The outcome of microfracture correlates most significantly with the Henderson score, subchondral edema, and repair tissue signal.
✅ Mesenchymal Stem Cells (MSCs) and Cartilage Restoration
- MSCs can be derived from bone marrow, synovium, adipose tissue, and umbilical cord
Advantages of hUCB-MSCs
- Non-invasive cell collection, high expansion capacity, and low immunogenicity
- Suitable for off-the-shelf allogeneic product applications
- Enables one-stage surgeries without additional autologous tissue harvests
References
- Clin Imaging. 2019 Nov-Dec;58:129-139.
- Semin Musculoskelet Radiol. 2022 Jun;26(3):216-229.
- Semin Musculoskelet Radiol 2018;22:377–385.
- Sci Rep. 2024 Mar 1;14(1):5133.
"Visualizing MSK Radiology: A Practical Guide to Radiology Mastery"
© 2022 MSK MRI Jee Eun Lee All Rights Reserved.
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#CartilageRepair, #OsteochondralDefect, #GraftSignalIntensity, #BoneIntegration, #SubchondralEdema, #Synovitis, #MicrofractureOutcomes, #MSCTherapy, #StemCellResearch, #OrthopedicSurgery
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| (Fig 5-C.04) Delamination and Graft Failure of hUCB-MSCs Implantation (0) | 2024.07.17 |
| (Fig 5-C.03) Illustrations of Cartilage Repair Failure (0) | 2024.07.17 |
| (Fig 5-C.02) MRI Findings of Autologous Matrix-Induced Chondrogenesis (0) | 2024.07.17 |