(Fig 5-C.02) MRI Findings of Autologous Matrix-Induced Chondrogenesis

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MSK MRI Jee Eun Lee

Visualizing MSK Radiology: A Practical Guide to Radiology Mastery

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📌 Autologous Matrix-Induced Chondrogenesis (AMIC)

• Autologous matrix-induced chondrogenesis (AMIC) is a surgical technique designed to enhance the effectiveness of arthroscopic microfracture procedures.

 

✅ Procedure

1. Curettage: Cleaning the cartilage defect area.
2. Microfracture: Creating small fractures in the exposed subchondral bone to form channels for bone marrow stem cells to migrate to the damaged area.
3. Membrane Attachment: Attaching a collagen I/III membrane to the damaged area using sutures or allogenic fibrin glue.

 

✅ Indications and Efficacy

• AMIC is typically used to treat articular cartilage defects greater than 2 cm². 
• Clinical studies have shown that AMIC can significantly improve symptoms in patients.

 

✅ Potential Complications

Clinicians should monitor for the following potential complications, which may lead to poor clinical outcomes:

• New cyst formation
• Partial detachment of the collagen membrane
• Accompanying synovitis

 

✅ Bone Marrow Stimulation (Microfracture)

• Bone marrow stimulation, also known as microfracture, is a key component of the AMIC procedure. 
• However, bone overgrowth has been observed in 25% to 49% of cases, though its clinical significance remains uncertain.

 

References

• Knee Surg Relat Res. 2022 Jan 28;34(1):1
• Semin Musculoskelet Radiol 2018;22:377–385
• Semin Musculoskelet Radiol 2011;15:69–88

 

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#AMIC, #CartilageRepair, #Microfracture, #OrthopedicSurgery, #KneeSurgery, #StemCellTherapy, #CollagenMembrane, #ArticularCartilage, #BoneMarrowStimulation, #ClinicalOutcomes