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📌 Primary Physis and Secondary Ossification Center
✅ Introduction to Hyaline Cartilage
- Hyaline cartilage is highly cellular, constituting up to 75% of its volume.
- It plays a critical role in synthesizing new bone from cartilage, a process known as endochondral ossification.
✅ Primary Physis and Longitudinal Bone Growth
- The primary physis is a thin disk located between the epiphyseal cartilage and metaphysis.
- It is responsible for the longitudinal growth of bones.
- Chondrocytes in the physis are arranged in columns parallel to the long axis of the bone.
Chondrocyte Development and Ossification
- Chondrocytes originate in the germinal layer on the epiphyseal side of the physis.
- As they move toward the metaphysis, they undergo proliferation, hypertrophy, and apoptosis.
- Mineralization of the matrix occurs in the zone of provisional calcification (ZPC).
✅ Secondary Ossification Center (SOC)
- The SOC enlarges by endochondral ossification similar to the primary physis.
- The germinal layer of the secondary physis is on the external aspect of the developing SOC.
- Columns of chondrocytes in the SOC are arranged radially.
References:
- RadioGraphics 2014; 34:449–471
"Visualizing MSK Radiology: A Practical Guide to Radiology Mastery"
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#bonegrowth, #hyalinecartilage, #endochondralossification, #chondrocytes, #primaryphysis, #longitudinalgrowth, #provisionalcalcification, #secondaryossification, #SOC, #medicalresearch
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