[Advanced] Fail​​ed Allogenic Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells, Cartistem

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📌  hUCB-MSCs (Cartistem®)

• Cartistem: A medicinal product developed by Medipost using human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) combined with hyaluronic acid hydrogel.
• Source: hUCB-MSCs are collected noninvasively from umbilical cord blood during neonatal delivery with maternal consent and stored in cord blood banks.

 

✅ Procedure for Cartilage Repair

• Method: Drill holes (4 mm and 2 mm in diameter, 5 mm depth) were created at the cartilage defect site on the femoral condyle, approximately 2–3 mm apart.
• Application: The hUCB-MSC-based hydrogel was implanted into these holes, filling the lesion from the base to the surface.

 

✅ Advantages of hUCB-MSCs

• Accessibility: Readily available from cord blood banks.
• Noninvasive Collection: Simple and safe collection process during childbirth.
• Low Immunogenicity: Reduces the risk of immune rejection.
• Proven Efficacy: Preclinical studies support their role in cartilage regeneration.

 

References

Arthroscopy. 2021 Aug; 37(8):2521-2530.

Am J Sports Med 2017;45:1845-1855.

Cytotherapy 2007;9: 717-726.

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📌 Graft Failure of hUCB-MSCs Implantation

 

• Delamination can be identified by displacement of all or a portion of the graft from the repair site or linear high signal intensity between the repair tissue and underlying bone. 
• Subjacent edemalike marrow signal intensity is usually present when delamination has occurred.

 

✅ Indicators of Poor Integration

• A linear high signal intensity between the repair tissue and underlying bone, representing delamination, may indicate a poor integration of the repair tissue and potential treatment failure.

• In delamination of surgically repaired cartilage, there is failure of the repair tissue to integrate with the subchondral bone, resulting in separation of the repaired cartilage from the underlying subchondral bone.

 

References

1. Radiology 2015; 277:23–43
2. Semin Musculoskelet Radiol 2022;26:216–229
3. MRI Web Clinic – June 2021 Tissue Delamination

 

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#Delamination, #Radiology, #MRI, #CartilageRepair, #SubchondralBone, #MedicalImaging, #TissueIntegration, #SurgicalRepair, #BoneMarrowEdema, #MusculoskeletalRadiology